Synthesis and evaluation of mefway analogs as ligands for serotonin 5HT1A receptors
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چکیده
منابع مشابه
Aporphine Alkaloids as Ligands for Serotonin Receptors
The aporphine alkaloids are known to have affinities as the dopaminergic, adrenergic and serotonergic receptor system. Hence the aporphine template can be considered as a privileged scaffold for the design of selective monopotent as well as multi-potent Central Nervous System (CNS) ligands. This review attempts to summarize the recent Structure Activity Relationship (SAR) studies of aporphine a...
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چکیده ندارد.
First-in-human evaluation of 18F-mefway, a PET radioligand specific to serotonin-1A receptors.
UNLABELLED The serotonin-1A (5-HT1A; 5-HT is 5-hydroxytryptamine) receptor is implicated in an array of neurologic and psychiatric disorders. Current PET radioligands targeting 5-HT1A receptors have limitations hindering widespread PET studies of this receptor system. The 5-HT1A-specific antagonist radioligand N-{2-[4-(2-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(trans-4-(18)F-fluorometh...
متن کاملBioisosteric Matrices for Ligands of Serotonin Receptors
The concept of bioisosteric replacement matrices is applied to explore the chemical space of serotonin receptor ligands, aiming to determine the most efficient ways of manipulating the affinity for all 5-HT receptor subtypes. Analysis of a collection of over 1 million bioisosteres of compounds with measured activity towards serotonin receptors revealed that an average of 31 % of the ligands for...
متن کاملCorrection: 18F-Mefway PET Imaging of Serotonin 1A Receptors in Humans: A Comparison with 18F-FCWAY
In the Funding section, the grant number from the funder Yonsei University College of Medicine is listed incorrectly. The correct grant number is: 6-2008-0237. access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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ژورنال
عنوان ژورنال: Medicinal Chemistry Research
سال: 2014
ISSN: 1054-2523,1554-8120
DOI: 10.1007/s00044-014-1238-z